Dr. Jason N. Berman, MD, FRCPC, FAAP
Professor, Department of Pediatrics, Division of Hematology/Oncology; cross appointed to Department of Microbiology & Immunology and Pathology; Staff Pediatric Hematologist/Oncologist, IWK Health Centre
Dalhousie University Faculty of Medicine, IWK Health Centre
Developing and using zebrafish models of Childhood cancers and Leukemia in particular to study the disease and test potential new therapies; cancer genetics; hematopoiesis and specifically mast cell development
Fishing for answers to leukemia
Dr. Jason Berman’s diverse and highly collaborative research program has applied zebrafish to investigate transcriptional regulation of mast cells; develop personalized therapy for childhood leukemia; determine key transcription factors and microenvironmental cytokines in cancer metastasis; and model bone marrow failure syndromes and hereditary retinal disorders. Dr. Berman and his team are the first to identify a mast cell equivalent in the zebrafish. They are currently using zebrafish to model allergic, inflammatory and malignant mast cell diseases.
Membership Status:Dr. Berman is a BHCRI Senior Scientist, a past member of the CRTP Management Committee, a supervisor for CRTP trainees and holds The CCNS Peggy Davison Clinician Scientist Award administered through BHCRI.
Address:IWK Health Centre, 5850/5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8
Wertman J, Veinotte CJ, Dellaire G, Berman JN. The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool. Adv Exp Med Biol. 2016;916:289-314.
LeBlanc MA, Bettle A, Berman JN, Price VE, Pambrun C, Yu Z, Tiller M, McMaster CR, Fernandez CV. Study of Glycine and Folic Acid Supplementation to Ameliorate Transfusion Dependence in Congenital SLC25A38 Mutated Sideroblastic Anemia. Pediatr Blood Cancer. 2016 Jul;63(7):1307-9.
Sultana S, Truong NY, Vieira DB, Wigger JG, Forrester AM, Veinotte CJ, Berman JN, van der Spoel AC. Characterization of the Zebrafish Homolog of β-Glucosidase 2: A Target of the Drug Miglustat. Zebrafish. 2016 Jun;13(3):177-87.
Prykhozhij SV, Rajan V, Berman JN. A Guide to Computational Tools and Design Strategies for Genome Editing Experiments in Zebrafish Using CRISPR/Cas9. Zebrafish. 2016 Feb;13(1):70-3.
J Fernández-Murray JP, Prykhozhij SV, DufayN, Steele SI, Gaston D, Nasrallah GK, Coombs AJ, Fernandez CV, Berman JN, and McMaster CR. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. PLoS Genetics. 2016 Jan 28;12(1).
Prykhozhij SV, Rajan V, Berman JN. A Guide to Computational Tools and Design Strategies for Genome Editing Experiments in Zebraﬁsh Using CRISPR/Cas9. TechnoFish Methods. Zebrafish 2016 Feb;13(1):70-3.