The Beatrice Hunter Cancer Research Institute logo
  • Dr. David Hoskin, PhD

Appointments:

Professor, Departments of Pathology, Microbiology & Immunology and Surgery
Affiliated Scientist, Department of Pathology and Laboratory Medicine, Capital Health
Canadian Breast Cancer Foundation-Atlantic Region Endowed Chair in Breast Cancer Research

Affiliations:

Dalhousie University Faculty of Medicine, Capital Health

Research Interests:

Anti-cancer potential of natural-source compounds, including cationic antimicrobial peptides and phytochemicals found in common spices; manipulation of T lymphocyte signal transduction for cancer control

Exploring the cancer-fighting potential of food and spice derivatives

Dr. David Hoskin has found that a fragment of milk protein known as lactoferricin triggers the death of cancer cells obtained from a wide range of human malignancies, including breast, colon and ovarian tumours and various leukemias and lymphomas. He is working on methods to deliver lactoferricin and other anti-cancer peptides directly to cancer cells. Dr. Hoskin is also investigating the anti-cancer activity of molecules found in common spices like turmeric and black pepper.

Membership Status:

Dr. Hoskin is a BHCRI Senior Scientist, has served on the BHCRI Working Group, BHCRI Development Board, CRTP Management Committee, BHCRI Training Committee and has been a supervisor for CRTP trainees.

Phone:

(902) 494-6509

Email:

d.w.hoskin@dal.ca

Address:

Sir Charles Tupper Medical Building, Dalhousie University Faculty of Medicine, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

Publications:

Douglas S, Hoskin DW, and Hilchie A. 2014. Assessment of antimicrobial (host defense) peptides as anti-cancer agents. Methods Mol Biology 1078: 159-170.

Hilchie AL, Conrad DM, Zemlak TS, Doucette CD, Liwski RS, and Hoskin DW. 2013. Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts. Leuk Lymphoma 54: 2255-2262.

Hilchie AL, Vale R, Zemlak T, and Hoskin DW. 2013. Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin. Exp Mol Pathol. 95:192-198.

Doucette CD, Hilchie A, Liwski R, and Hoskin DW. 2013. Piperine, a dietary phytochemical, inhibits angiogenesis. J Nutr Biochem 24:231-239.

Yaffe P, Doucette CD, Walsh M, and Hoskin DW. 2013. Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in HRT-18 rectal cancer cells. Exp Mol Pathol 94: 109-114.

Hilchie AL, Power Coombs MR, and Hoskin DW. 2012. Obstacles and solutions to the use of cationic antimicrobial peptides in the treatment of cancer. In Small Wonders: Peptides for Disease Control (K. Rajasekaran, J.W. Cary, J.M. Jaynes, E. Montesinos, Eds.), pp. 61-78. ACS Publications, Washington, DC.

Sutton K, Doucette CD, and Hoskin DW. 2012. NADPH quinine oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis. Biochem Biophys Res Comm 426:421-426.

Hilchie A, Doucette CD, Pinto D, Patrzykat A, Douglas S, and Hoskin DW. 2011. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res 13: R102.

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