Dr. Brent Johnston, PhD
Professor, Department of Microbiology & Immunology, joint-appointed to Department of Pediatrics, cross-appointed to Department of Pathology
Canada Research Chair in Inflammation and Immunity
Dalhousie University Faculty of Medicine
Mechanisms of immune activation and cell recruitment; adhesion molecules, chemokines, and cytokines; roles of NKT cells and γΔ T cells in inflammation and cancer
Stimulating natural immunity against cancer
Natural Killer T (NKT) cells are a rare population of white blood cells with the potential to become powerful natural allies in the body’s efforts to fight cancer. Dr. Johnston is studying how signalling proteins and receptors can be manipulated to stimulate the NKT cells to mount an aggressive immune response, and to direct that response to the primary tumour location to eliminate the cancer at its source. He and his team are also examining the effects of immune-modulating compounds on NKT cell anti-tumour activity.